Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
FAQs About The Sinclair Method: What You Really Need to Know
The Sinclair Method is a treatment for Alcohol Use Disorder (AUD) that involves taking the medication naltrexone one to two hours before drinking. Naltrexone blocks endorphins released by alcohol, reducing the brain’s reinforcement of drinking behaviour. Over time, this leads to a natural decrease in alcohol consumption—a process known as pharmacological extinction.
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